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Thesis

Multilocus approaches to the detection of disease susceptibility regions: methods and applications

Abstract:

This thesis focuses on multilocus methods designed to detect single nucleotide polymorphisms (SNPs) that are associated with disease using case-control data. I study multilocus methods that allow for interaction in the regression model because epistasis is thought to be pervasive in the etiology of common human diseases. In contrast, the single-SNP models widely used in genome wide association studies (GWAS) are thought to oversimplify the underlying biology. I consider both pairwise inter...

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Institution:
University of Oxford
Oxford college:
Lincoln College
Department:
Mathematical,Physical & Life Sciences Division - Statistics
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Julia Grant Ciampa
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:8f82a624-7d80-438c-af3e-68ce983ff45f
Local pid:
ora:5886

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