Journal article
Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine
- Abstract:
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The cellular mechanism(s) linking macrophages to norepinephrine (NE)-mediated regulation of thermogenesis have been a topic of debate. Here we identify sympathetic neuron-associated macrophages (SAMs) as a population of cells that mediate clearance of NE via expression of solute carrier family 6 member 2 (SLC6A2), an NE transporter, and monoamine oxidase A (MAOA), a degradation enzyme. Optogenetic activation of the sympathetic nervous system (SNS) upregulates NE uptake by SAMs and shifts the ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 429.1KB)
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- Publisher copy:
- 10.1038/nm.4422
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Authors
Funding
Maratona da Saúde
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Human Frontier Science Program
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National Institutes of Health
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Fundação para a Ciéncia e Tecnologia
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European Molecular Biology Organization
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Medicine Journal website
- Volume:
- 23
- Issue:
- 1
- Pages:
- 1309–1318
- Publication date:
- 2017-10-09
- Acceptance date:
- 2017-09-12
- DOI:
- EISSN:
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1546-170X
- ISSN:
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1078-8956
- Pmid:
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29035364
- Source identifiers:
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864441
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:864441
- UUID:
-
uuid:8fa8f790-9f00-4c2f-8749-804fd67157e9
- Local pid:
- pubs:864441
- Deposit date:
- 2018-08-09
Terms of use
- Copyright holder:
- Nature America
- Copyright date:
- 2017
- Notes:
- © 2017 Nature America, Inc., part of Springer Nature. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/nm.4422.
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