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Journal article

Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine

Abstract:

The cellular mechanism(s) linking macrophages to norepinephrine (NE)-mediated regulation of thermogenesis have been a topic of debate. Here we identify sympathetic neuron-associated macrophages (SAMs) as a population of cells that mediate clearance of NE via expression of solute carrier family 6 member 2 (SLC6A2), an NE transporter, and monoamine oxidase A (MAOA), a degradation enzyme. Optogenetic activation of the sympathetic nervous system (SNS) upregulates NE uptake by SAMs and shifts the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nm.4422

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Role:
Author
ORCID:
0000-0003-2314-0439
More by this author
Role:
Author
ORCID:
0000-0003-2819-2051
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Maratona da Saúde More from this funder
Human Frontier Science Program More from this funder
National Institutes of Health More from this funder
Fundação para a Ciéncia e Tecnologia More from this funder
European Molecular Biology Organization More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Medicine Journal website
Volume:
23
Issue:
1
Pages:
1309–1318
Publication date:
2017-10-09
Acceptance date:
2017-09-12
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Pmid:
29035364
Source identifiers:
864441
Language:
English
Keywords:
Pubs id:
pubs:864441
UUID:
uuid:8fa8f790-9f00-4c2f-8749-804fd67157e9
Local pid:
pubs:864441
Deposit date:
2018-08-09

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