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Thesis

Chemical tools for the study of epigenetic mechanisms

Abstract:

The overall goal of my work was to develop and apply new chemical methods for the study of epigenetic DNA and protein modifications.

In Chapter 3 the development of Suzuki-Miyaura cross coupling (SMcc) for the post-synthetic modification of DNA is described. DNA modification by SMcc is efficient (4-6h) and proceeds under mild conditions (37°C, pH 8.5). The incorporation of various groups useful for biological investigations is demonstrated using this methodology. Using a photocrossl...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Oxford college:
Somerville College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:8fec2af6-573b-464a-865e-a70d31fa1c41
Local pid:
ora:9271
Deposit date:
2014-11-07

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