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Engineering a uniaxial substrate-stretching device for simultaneous electrophysiological measurements and imaging of strained peripheral neurons

Abstract:

Peripheral nerves are continuously subjected to mechanical strain during everyday movements, but excessive stretch can lead to damage and neuronal cell functionality can also be impaired. To better understand cellular processes triggered by stretch, it is necessary to develop in vitro experimental methods that allow multiple concurrent measurements and replicate in vivo mechanical conditions. Current commercially available cell stretching devices do not allow flexible experimental design, res...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.medengphy.2019.02.014

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Oxford college:
Balliol College
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Medical Engineering & Physics Journal website
Volume:
67
Pages:
1-10
Publication date:
2019-03-14
Acceptance date:
2019-02-25
DOI:
EISSN:
1873-4030
ISSN:
1350-4533
Pmid:
30878301
Source identifiers:
983960
Language:
English
Keywords:
Pubs id:
pubs:983960
UUID:
uuid:90511ba9-1ffa-4ace-ba7f-1c0e40a55340
Local pid:
pubs:983960
Deposit date:
2019-03-26

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