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Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility

Abstract:

BACKGROUND:
Gene drives based on CRISPR-Cas9 technology are increasingly being considered as tools for reducing the capacity of mosquito populations to transmit malaria, and one of the most promising options is driving endonuclease genes that reduce the fertility of female mosquitoes. In particular, there is much interest in constructs that target the conserved mosquito doublesex (dsx) gene such that the emergence of functional drive-resistant alleles is unlikely. Proof of principle that t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12915-020-00834-z

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Sub department:
Zoology
Role:
Author
ORCID:
0000-0002-4253-396X
Publisher:
BioMed Central Publisher's website
Journal:
BMC Biology Journal website
Volume:
18
Issue:
1
Article number:
98
Publication date:
2020-08-11
Acceptance date:
2020-07-22
DOI:
EISSN:
1741-7007
Pmid:
32782000
Language:
English
Keywords:
Pubs id:
1125932
Local pid:
pubs:1125932
Deposit date:
2020-10-05

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