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Synthesis and reactivity of novel γ-phosphate modified ATP analogues

Abstract:
We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27kip1 is also presented. © 2009 Elsevier Ltd. All rights reserved.

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Publisher copy:
10.1016/j.bmcl.2009.04.028

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Journal:
Bioorganic and Medicinal Chemistry Letters
Volume:
19
Issue:
14
Pages:
3804-3807
Publication date:
2009-07-15
DOI:
ISSN:
0960-894X
Source identifiers:
134370
Language:
English
Keywords:
Pubs id:
pubs:134370
UUID:
uuid:9074fcf0-dd45-4bcc-a214-1a4e25c524f7
Local pid:
pubs:134370
Deposit date:
2012-12-19

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