Journal article
Synthesis and reactivity of novel γ-phosphate modified ATP analogues
- Abstract:
- We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27kip1 is also presented. © 2009 Elsevier Ltd. All rights reserved.
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- Publisher copy:
- 10.1016/j.bmcl.2009.04.028
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Bibliographic Details
- Journal:
- Bioorganic and Medicinal Chemistry Letters
- Volume:
- 19
- Issue:
- 14
- Pages:
- 3804-3807
- Publication date:
- 2009-07-15
- DOI:
- ISSN:
-
0960-894X
- Source identifiers:
-
134370
Item Description
Terms of use
- Copyright date:
- 2009
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