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Thesis

Structural and functional studies of cell surface receptors

Abstract:

Receptor proteins on the surfaces of cells equip them to communicate with each other and to sense and interact with their environment. One receptor family, the αβ T-cell receptors (TCRs), allow T lymphocytes to detect and respond to pathogens via interactions with antigen-presenting major histocompatibility complex (MHC) molecules on target cells. A degree of TCR cross-reactivity (e.g. through structural similarity between peptide-MHC (pMHC) complexes) is essential to account for all pos...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Research group:
Professor E. Yvonne Jones - Division of Structural Biology
Oxford college:
Trinity College
Role:
Author

Contributors

Role:
Supervisor
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Funding agency for:
Border, E
Grant:
RPSJ0
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:907793da-3ba1-4a57-8bdb-c185aa84c28c
Local pid:
ora:6992
Deposit date:
2013-07-12

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