Thesis icon

Thesis

The role of the oocyte activation factor PLCzeta in human male factor infertility

Abstract:

General consensus agrees that the oscillations in intracellular calcium (Ca2+) leading to oocyte activation are induced by a testis-specific phospholipase C, PLCzeta (PLCζ). Strong evidence now indicates that certain types of human infertility are caused by failure of the sperm to activate the oocyte in an appropriate manner. Such sperm exhibit absent/reduced levels of PLCζ, while molecular analysis of the PLCζ gene in an infertile patient identified a substitution of a conserved histidin...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Research group:
Dr Kevin Coward Research Group
Oxford college:
Worcester College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP