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Studies of intestinal inflammation: the roles of IL-23R, gamma-delta T-cells and IL-21i

Abstract:

The aetiology of the inflammatory bowel diseases ulcerative colitis and Crohn’s disease remains uncertain. Genetic studies and model systems strongly implicate components of the IL-23/type-17 axis in the pathogenesis of disease, but the cellular and molecular mediators are uncertain. Using an IL-23Rgfp reporter mouse we analysed the cellular expression of IL-23R in homeostasis and disease. Whereas steady state expression in the intestine was dominated by a collection of unconven...

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  • (Dissemination version, pdf, 7.9MB)

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Translational Gastroenterology Unit
Oxford college:
Linacre College
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
More from this funder
Funding agency for:
Shale, M
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:90aa31d4-a216-44b4-8a0b-7964886b3583
Local pid:
ora:10283
Deposit date:
2015-03-18

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