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Thesis

Monitoring and controlling GABAergic interneuron subtypes during epileptiform activity

Alternative title:
Inhibitory neurons in epilepsy
Abstract:

Inhibitory synaptic transmission is of paramount importance for maintaining the delicate balance between excitation and inhibition in the brain. If this balance is perturbed in favour of excitation, epilepsy is likely to develop. Fast synaptic inhibition is mediated by type A γ-aminobutyric acid ionotropic receptors (GABAARs), which are primarily permeable to Cl. The strength of synaptic inhibition crucially depends on the release of GABA from different populations o...

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Division:
MSD
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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