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Normoxic stabilization of hypoxia-inducible factor-1α by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

Abstract:

Hypoxia-inducible factor (HIF) is a transcription factor with major roles in many cellular and systemic responses to hypoxia. Activation of HIF pathways under hypoxia is mediated by suppression of the Fe²⁺ - and O₂-dependent HIF hydroxylase enzymes that normally inactive HIFα subunits. Mechanisms underlying induction of HIF in normoxic conditions are less clearly understood. In human cancers, infiltrating macrophages show up-regulation of HIF and it has recently been shown that normoxic expre...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Research group:
Cancer Research UK Molecular Oncology Laboratory
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Funding agency for:
Mole, D
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Funding agency for:
Knowles, H
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Funding agency for:
Ratcliffe, P
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Funding agency for:
Harris, A
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Research Journal website
Volume:
66
Issue:
5
Pages:
2600-2607
Publication date:
2006-03-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Language:
English
Subjects:
UUID:
uuid:91dc7093-954a-4ef9-95ec-636edd4369f9
Local pid:
ora:6312
Deposit date:
2012-06-27

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