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Journal article

Origins of the mechanochemical coupling of peptide bond formation to protein synthesis

Abstract:

Mechanical forces acting on the ribosome can alter the speed of protein synthesis, indicating that mechanochemistry can contribute to translation control of gene expression. The naturally occurring sources of these mechanical forces, the mechanism by which they are transmitted 10 nm to the ribosome’s catalytic core, and how they influence peptide bond formation rates are largely unknown. Here, we identify a new source of mechanical force acting on the ribosome by using in situ experimental me...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/jacs.7b11044

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Division:
MPLS
Department:
Statistics
Role:
Author
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
140
Issue:
15
Pages:
5077-5087
Publication date:
2018-03-26
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pmid:
29577725
Language:
English
Keywords:
Pubs id:
986159
Local pid:
pubs:986159
Deposit date:
2020-08-27

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