Journal article
Recapitulation of developmental mechanisms to revascularise the ischemic heart
- Abstract:
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Restoring blood flow after myocardial infarction (MI) is essential for survival of existing and newly regenerated tissue. Endogenous vascular repair processes are deployed following injury, but are poorly understood. We sought to determine whether developmental mechanisms of coronary vessel formation are intrinsically reactivated in the adult mouse post-MI. Using pulse-chase genetic lineage tracing, we establish that de novo vessel formation constitutes a significant component of the neovascu...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(pdf, 17.6MB)
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- Publisher copy:
- 10.1172/jci.insight.96800
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Authors
Funding
+ British Heart Foundation
More from this funder
Grant:
RM/13/3/30159;ResearchFellowships
Studentships
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- JCI Insight Journal website
- Volume:
- 2
- Issue:
- 22
- Pages:
- 96800
- Publication date:
- 2017-11-16
- Acceptance date:
- 2017-10-11
- DOI:
- ISSN:
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2379-3708
Item Description
- Pubs id:
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pubs:737073
- UUID:
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uuid:9223b818-60b5-435b-865c-c7b3487ce632
- Local pid:
- pubs:737073
- Deposit date:
- 2017-10-19
Terms of use
- Copyright holder:
- Dubé et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Dubé et al. Open access: this work is licensed under the Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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