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Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart

Abstract:

Macrophages are components of the innate immune system with key roles in tissue inflammation and repair. It is now evident that macrophages also support organogenesis, but few studies have characterized their identity, ontogeny and function during heart development. Here, we show that the distribution and prevalence of resident macrophages in the subepicardial compartment of the developing heart coincides with the emergence of new lymphatics, and that macrophages interact closely with the nas...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dev.194563

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0002-2881-6744
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Grant:
FS/19/31/34158
PG/10/60/28496
Publisher:
The Company of Biologists Publisher's website
Journal:
Development Journal website
Volume:
148
Issue:
3
Article number:
dev194563
Publication date:
2021-02-03
Acceptance date:
2020-06-30
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Language:
English
Keywords:
Pubs id:
1092337
Local pid:
pubs:1092337
Deposit date:
2020-09-08

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