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Thesis

Synthetic post- translational protein modification as a switch for activity

Abstract:

The ‘post-translational mutagenesis’ chemistry, utilising a bio-orthogonal radical reaction with Dha on proteins, has opened up a vast range of novel possibilities in generating post- translational modification (PTM) mimics. Two case studies are described in this thesis, around the theme of PTMs as switches for protein-protein interactions. The first case study recapitulates the natural PTMs H3K36me2 and -me3. Functional evidence from in vivo observations suggests that the chromodomain reader...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Research group:
Ben Davis & Fumiko Esashi
Oxford college:
University College
Role:
Author
ORCID:
0000-0002-6085-7423

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Sub department:
Pathology Dunn School
Role:
Supervisor
Role:
Examiner
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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