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Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Abstract:

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide an...

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Publication status:
Published

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Publisher copy:
10.1038/nature13545

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Journal:
Nature
Volume:
514
Issue:
7520
Pages:
92-97
Publication date:
2014-10-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
485119

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