Journal article
CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.
- Abstract:
-
CTL play a critical role in the control of HIV and SIV. However, intrinsic genetic instability enables these immunodeficiency viruses to evade detection by CTL through mutation of targeted antigenic sites. These mutations can impair binding of viral epitopes to the presenting MHC class I molecule or disrupt TCR-mediated recognition. In certain regions of the virus, functional constraints are likely to limit the capacity for variation within epitopes. Mutations elsewhere in the protein, howeve...
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- Publication status:
- Published
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- Publisher copy:
- 10.4049/jimmunol.175.7.4618
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Authors
Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 175
- Issue:
- 7
- Pages:
- 4618-4626
- Publication date:
- 2005-10-01
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
5484
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:5484
- UUID:
-
uuid:92ee64e0-b7a7-43fb-9943-3e9014a76dfd
- Local pid:
- pubs:5484
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2005
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