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Thesis

Targeting cell adhesion as a method of sensitising metastatic tumour cells to TRAIL-induced apoptosis

Abstract:

Due to its selectivity in killing cancer cells, Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has provided a potential new agent for cancer treatment. However, despite promising pre-clinical results, it appears that TRAIL therapies will be most effective when used in combination with a sensitizing agent. In light of previous evidence suggesting that cell adhesion could influence sensitivity to Tumour necrosis factor family ligands, this thesis presents a study of the eff...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Oxford college:
Linacre College
Role:
Author

Contributors

Role:
Supervisor
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Funding agency for:
Phipps, L
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:93198943-a7fa-4b30-aaed-c92d7e0a4ba6
Local pid:
ora:6224
Deposit date:
2012-05-10

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