Comparative neurotranscriptomics in mammals and birds

Thesis

In this thesis I apply new sequencing technologies and analytical methods derived from genomics and computer science to the neuroanatomy of gene expression. The first project explores characteristics of gene expression across adult neocortical layers in a representative mammal – the mouse. Amongst the thousands of genes and transcripts differentially expressed across layers, I found common functional characteristics of genes that define certain layers, candidate cases of isoform switching, ...

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Authors: Belgard, TG

• Publication date: 2011
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: neuroanatomy; RNA-seq; transcriptome; birds; comparative neuroanatomy; sequencing; comparative neurotranscriptomics; mammals
• Subjects: Neuroscience; Physiology and anatomy; Anatomy; Neurogenetics; Bioinformatics (biochemistry); Zoological sciences; Bioinformatics (technology); Medical sciences; Evolution (zoology); Life Sciences; Bioinformatics (life sciences); Molecular genetics; Mathematical genetics and bioinformatics (statistics); Biochemistry; Biology; Biology (medical sciences); Genetics (life sciences)