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Thesis

Investigation of the contribution of cutaneous HPV E6 proteins towards the development of non melanoma skin cancer

Abstract:

Sunlight is the main aetiological agent in the development of non melanoma skin cancer (NMSC), the most commonly diagnosed cancer in the fair skinned population. Mounting epidemiological and molecular data suggest that infection with cutaneous Human papillomavirus (HPV) may act as a co-factor in the early stages of NMSC development. The viral E6 protein can inhibit the apoptotic response to UV induced damage, partly through proteasomal degradation of the pro-apoptotic protein BAK. Upon UV ...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Research group:
Cell Death Regulation Group
Oxford college:
Queen's College
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Role:
Supervisor
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Funding agency for:
Holloway, AF
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:9369b19d-21f7-44fd-b48a-aa3f3d59e456
Local pid:
ora:7465
Deposit date:
2013-10-17

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