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Journal article

Temperature regulates NF-κB dynamics and function through timing of A20 transcription

Abstract:

NF-κB signaling plays a pivotal role in control of the inflammatory response. We investigated how the dynamics and function of NF-κB were affected by temperature within the mammalian physiological range (34 °C to 40 °C). An increase in temperature led to an increase in NF-κB nuclear/cytoplasmic oscillation frequency following Tumor Necrosis Factor alpha (TNFα) stimulation. Mathematical modeling suggested that this temperature sensitivity might be due to an A20-dependent mechanism, and A20 sil...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1803609115

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Role:
Author
ORCID:
0000-0002-5408-0013
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Grant:
FP7 Health (HEALTH) 305564
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
22
Pages:
E5243-E5249
Publication date:
2018-05-14
Acceptance date:
2018-04-27
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
915914
Keywords:
Pubs id:
pubs:915914
UUID:
uuid:9398eba5-3cfa-46c1-b4f0-4b7f34a08fa8
Local pid:
pubs:915914
Deposit date:
2018-09-13

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