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Prospective multicentre randomised, double-blind, equivalence study comparing clonidine and midazolam as intravenous sedative agents in critically ill children: the SLEEPS (Safety profiLe, Efficacy and Equivalence in Paediatric intensive care Sedation) study

Abstract:

Background

Children in paediatric intensive care units (PICUs) require analgesia and sedation but both undersedation and oversedation can be harmful.

Objective

Evaluation of intravenous (i.v.) clonidine as an alternative to i.v. midazolam.

Design

Multicentre, double-blind, randomised equivalence trial.

Setting

Ten UK PICUs.

Participants

Childre...

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Publication status:
Published
Peer review status:
Reviewed (other)

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Files:
Publisher copy:
10.3310/hta18710

Authors


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Publisher:
NIHR Journals Library Publisher's website
Issue:
71
Host title:
Health Technology Assessment
Publication date:
2014-12-01
DOI:
EISSN:
2046-4924
ISSN:
1366-5278
Paper number:
18
ISBN:
9780812242157
Keywords:
Pubs id:
pubs:500700
UUID:
uuid:944071e9-8d57-43c2-875b-ba3faee677df
Local pid:
pubs:500700
Deposit date:
2019-08-12

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