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Comparing different ways of calculating sample size for a randomised controlled trial using baseline and post-intervention measurements

Abstract:
In this paper, we compare different methods of calculating sample sizes for comparing two independent means of a continuous outcome with baseline and post-intervention measurements of a randomised controlled trial (RCT). Sample size calculations typically use published results from similar trials, and we illustrate the different methods using published results from the MOSAIC trial.
Publication status:
Published
Peer review status:
Reviewed (other)

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Publisher copy:
10.1186/s13063-017-1902-y

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; CSM
Oxford college:
Kellogg College
Role:
Author
ORCID:
0000-0001-5595-8468
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; CSM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Oxford college:
Balliol College
Role:
Author
Publisher:
BioMed Central Publisher's website
Host title:
4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials
Journal:
4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials Journal website
Publication date:
2017-05-01
Acceptance date:
2016-11-21
DOI:
EISSN:
1745-6215
Source identifiers:
734877
Pubs id:
pubs:734877
UUID:
uuid:9457caf5-d577-446d-b270-a3682771255d
Local pid:
pubs:734877
Deposit date:
2018-03-12

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