Thesis
Kinetic and mechanistic studies of oxygen sensing Fe(II)/2-oxoglutarate dependent oxygenases
- Abstract:
-
The Fe(II)/2-oxoglutarate (2OG) dependent oxygenases are a widespread enzyme family, which are characterised by structurally similar active sites and proposed to employ a common reaction mechanism. The work described in this thesis concerned kinetic and biophysical studies on 2OG oxygenases, with a particular focus on the hypoxia-inducible transcription factor (HIF) hydroxylases and mechanistic aspects of their reaction with oxygen.
The four human HIF hydroxylases regulate cellular ...
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Authors
Contributors
+ Schofield, C
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
+ Flashman, E
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:94924981-8b73-43ba-9d90-47a73b84e5f9
- Local pid:
- ora:11694
- Deposit date:
- 2015-06-22
Terms of use
- Copyright holder:
- Tarhonskaya, H
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available on ORA.
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