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Development of a polygenic risk score to improve screening for fracture risk: a genetic risk prediction study.

Abstract:

BACKGROUND:
Since screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could decrease the number needing to be screened by removing individuals at low genetic risk. We therefore tested whether a polygenic risk score for heel quantitative ultrasound speed of sound (SOS)-a heritable risk factor for osteoporotic fracture-can identify low-risk individuals who can safely be excluded from a fracture ri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-6061-4720
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Role:
Author
ORCID:
0000-0003-0887-0572
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Role:
Author
ORCID:
0000-0001-9290-8603
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Role:
Author
ORCID:
0000-0001-8956-2509
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Role:
Author
ORCID:
0000-0002-9105-2249
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
17
Issue:
7
Article number:
e1003152
Publication date:
2020-07-02
Acceptance date:
2020-06-03
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pmid:
32614825
Pubs id:
1116405
Local pid:
pubs:1116405

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