Journal article
Development of a polygenic risk score to improve screening for fracture risk: a genetic risk prediction study.
- Abstract:
-
BACKGROUND:
Expand abstract
Since screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could decrease the number needing to be screened by removing individuals at low genetic risk. We therefore tested whether a polygenic risk score for heel quantitative ultrasound speed of sound (SOS)-a heritable risk factor for osteoporotic fracture-can identify low-risk individuals who can safely be excluded from a fracture ri...
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 1.7MB)
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- Publisher copy:
- 10.1371/journal.pmed.1003152
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Medicine Journal website
- Volume:
- 17
- Issue:
- 7
- Article number:
- e1003152
- Publication date:
- 2020-07-02
- Acceptance date:
- 2020-06-03
- DOI:
- EISSN:
-
1549-1676
- ISSN:
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1549-1277
- Pmid:
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32614825
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1116405
- Local pid:
- pubs:1116405
- Deposit date:
- 2020-08-27
Terms of use
- Copyright holder:
- Forgetta et al.
- Copyright date:
- 2020
- Rights statement:
- ©2020 Forgetta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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