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Journal article

Inducibility, but not stability, of atrial fibrillation is increased by NOX2 overexpression in mice

Abstract:
Aims
Gp91-containing NADPH oxidases (NOX2) are a significant source of myocardial superoxide production. An increase in NOX2 activity accompanies atrial fibrillation (AF) induction and electrical remodelling in animal models and predicts incident AF in humans; however, a direct causal role for NOX2 in AF has not been demonstrated. Accordingly, we investigated whether myocardial NOX2 overexpression in mice (NOX2-Tg) is sufficient to generate a favourable substrate for AF a... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cvr/cvab019

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Volume:
117
Issue:
11
Pages:
2354–2364
Publication date:
2021-01-23
Acceptance date:
2021-01-13
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Pmid:
33483749
Language:
English
Keywords:
Pubs id:
1159180
Local pid:
pubs:1159180
Deposit date:
2021-02-05

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