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Journal article : Review

Epigenetic regulation of cancer stem cell formation and maintenance

Abstract:

Cancerous tumours contain a rare subset of cells with stem-like properties that are termed cancer stem cells (CSCs). CSCs are defined by their ability to divide both symmetrically and asymmetrically, to initiate new tumour growth and to tolerate the foreign niches required for metastatic dissemination. Accumulating evidence suggests that tumours arise from cells with stem-like properties, the generation of CSCs is therefore likely to be an initiatory event in carcinogenesis. Furthermore, CSCs...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1002/ijc.33398

Authors


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Role:
Author
ORCID:
0000-0003-1056-1576
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Author
Pancreatic Cancer UK More from this funder
Publisher:
Wiley Publisher's website
Journal:
International Journal of Cancer Journal website
Volume:
148
Issue:
12
Pages:
2884-2897
Publication date:
2020-11-30
Acceptance date:
2020-11-11
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Pmid:
33197277
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1146041
Local pid:
pubs:1146041
Deposit date:
2020-12-03

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