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Working paper

Origin of complexity in haemoglobin evolution

Abstract:

Most proteins associate into multimeric complexes with specific architectures1,2, which often have functional properties such as cooperative ligand binding or allosteric regulation3. No detailed knowledge is available about how any multimer and its functions arose during evolution. Here we use ancestral protein reconstruction and biophysical assays to elucidate the origins of vertebrate haemoglobin, a heterotetramer of paralogous α- and β-subunits that mediates respiratory oxygen transport an...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41586-020-2292-y

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Role:
Author
ORCID:
0000-0003-4994-5200
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Role:
Author
ORCID:
0000-0002-0664-0864
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Publisher:
Springer Nature Publisher's website
Volume:
581
Issue:
7809
Pages:
480-485
Host title:
Nature
Publication date:
2020-05-20
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Pubs id:
1088032
Local pid:
pubs:1088032
Deposit date:
2020-06-25

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