Journal article
Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel
- Abstract:
-
Centrioles are eukaryotic organelles that template the formation of cilia and flagella, as well as organize the microtubule network and the mitotic spindle in animal cells. Centrioles have proximal-distal polarity and a 9-fold radial symmetry imparted by a likewise symmetrical central scaffold, the cartwheel. The spindle assembly abnormal protein 6 (SAS-6) self-assembles into 9-fold radially symmetric ring-shaped oligomers that stack via an unknown mechanism to form the cartwheel. Here, we un...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Structure Journal website
- Volume:
- 30
- Issue:
- 5
- Pages:
- 671-684
- Publication date:
- 2022-03-02
- Acceptance date:
- 2022-02-04
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
Item Description
- Language:
- English
- Keywords:
- Deposit date:
- 2022-02-07
Terms of use
- Copyright holder:
- Kantsadi et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under a Creative Commons license.
- Licence:
- CC Attribution (CC BY)
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