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Journal article

Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance.

Abstract:

Although cytotoxic T lymphocytes (CTLs) in people infected with human immunodeficiency virus type 1 can potentially target multiple virus epitopes, the same few are recognized repeatedly. We show here that CTL immunodominance in regions of the human immunodeficiency virus type 1 group-associated antigen proteins p17 and p24 correlated with epitope abundance, which was strongly influenced by proteasomal digestion profiles, affinity for the transporter protein TAP, and trimming mediated by the ...

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Publication status:
Published

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Publisher copy:
10.1038/ni.1728

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Journal:
Nature immunology
Volume:
10
Issue:
6
Pages:
636-646
Publication date:
2009-06-01
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Source identifiers:
9985

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