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Shigella flexneri Spa15 crystal structure verified in solution by double electron electron resonance

Abstract:
Shigella flexneri Spa15 is a chaperone of the type 3 secretion system, which binds a number of effectors to ensure their stabilization prior to secretion. One of these effectors is IpgB1, a mimic of the human Ras-like Rho guanosine triphosphatase RhoG. In this study, Spa15 alone and in complex with IpgB1 has been studied by double electron electron resonance, an experiment that gives distance information showing the spacial separation of attached spin labels. This distance is explain... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jmb.2010.10.053

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
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Funding agency for:
Lovett, J
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Funding agency for:
Johnson, S
Grant:
083599
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Funding agency for:
Roversi, P
Grant:
083599
Publisher:
Elsevier Publisher's website
Journal:
Journal of Molecular Biology Journal website
Volume:
405
Issue:
2
Pages:
427-435
Publication date:
2011-01-01
DOI:
ISSN:
00222836
Language:
English
Keywords:
Subjects:
UUID:
uuid:96a2a86b-fde6-4eee-8bdf-c57a2d84bf67
Local pid:
ora:5587
Deposit date:
2011-07-19

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