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Journal article

Synthesis and demonstration of the biological relevance of sp3-rich scaffolds distantly related to natural product frameworks.

Abstract:

The productive exploration of chemical space is an enduring challenge in chemical biology and medicinal chemistry. Natural products are biologically relevant, and their frameworks have facilitated chemical tool and drug discovery. A "top-down" synthetic approach is described that enabled a range of complex bridged intermediates to be converted with high step efficiency into 26 diverse sp3 -rich scaffolds. The scaffolds have local natural product-like features, but are only distantly related t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1002/chem.201704169

Authors


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GlaxoSmithKline More from this funder
Innovative Medicines Initiative Joint Undertaking More from this funder
Boehringer Ingelheim More from this funder
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Publisher:
Wiley Publisher's website
Journal:
Chemistry Journal website
Volume:
23
Issue:
60
Pages:
15227-15232
Publication date:
2017-10-01
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Pmid:
28983993
Source identifiers:
737322
Language:
English
Keywords:
Pubs id:
pubs:737322
UUID:
uuid:96e9ac5c-6d03-4d63-9b95-4183f5c246c6
Local pid:
pubs:737322
Deposit date:
2017-11-14

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