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Self-organizing actin patterns shape membrane architecture but not cell mechanics

Abstract:

Cell-free studies have demonstrated how collective action of actin-associated proteins can organize actin filaments into dynamic patterns, such as vortices, asters and stars. Using complementary microscopic techniques, we here show evidence of such self-organization of the actin cortex in living HeLa cells. During cell adhesion, an active multistage process naturally leads to pattern transitions from actin vortices over stars into asters. This process is primarily driven by Arp2/3 complex nuc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms14347

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Edward Penley Abraham Cephalosporin Fund More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
14347
Publication date:
2017-02-13
Acceptance date:
2016-12-15
DOI:
EISSN:
2041-1723
Source identifiers:
680212
Language:
English
Keywords:
Pubs id:
pubs:680212
UUID:
uuid:96f6eba1-1c59-49a4-96d5-0c19c5f3b5ef
Local pid:
pubs:680212
Deposit date:
2017-03-18

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