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Journal article

Molecular mechanisms of T cell sensitivity to antigen

Abstract:

T cells initiate and regulate adaptive immune responses that can clear infections. To do this, they use their T cell receptors (TCRs) to continually scan the surfaces of other cells for cognate peptide antigens presented on major histocompatibility complexes (pMHCs). Experimental work has established that as few 1‐10 pMHCs are sufficient to activate T cells. This sensitivity is remarkable in light of a number of factors, including the observation that the TCR and pMHC are short molecules rela...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/imr.12690

Authors


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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-5847-5226
More from this funder
Funding agency for:
Siller-Farfán, J
Grant:
440334
More from this funder
Funding agency for:
Siller-Farfán, J
Grant:
440334
More from this funder
Funding agency for:
Siller-Farfán, J
Grant:
440334
More from this funder
Funding agency for:
Siller-Farfán, J
Grant:
440334
More from this funder
Funding agency for:
Dushek, O
Grant:
207537/Z/17/Z
Publisher:
Wiley Publisher's website
Journal:
Immunological Reviews Journal website
Volume:
285
Issue:
1
Publication date:
2018-08-11
Acceptance date:
2018-06-27
DOI:
EISSN:
1600-065X
Source identifiers:
860147
Keywords:
Pubs id:
pubs:860147
UUID:
uuid:9775efc3-8cf8-406b-bc9a-b0ecf18e189c
Local pid:
pubs:860147
Deposit date:
2018-07-02

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