Journal article
Molecular mechanisms of T cell sensitivity to antigen
- Abstract:
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T cells initiate and regulate adaptive immune responses that can clear infections. To do this, they use their T cell receptors (TCRs) to continually scan the surfaces of other cells for cognate peptide antigens presented on major histocompatibility complexes (pMHCs). Experimental work has established that as few 1‐10 pMHCs are sufficient to activate T cells. This sensitivity is remarkable in light of a number of factors, including the observation that the TCR and pMHC are short molecules rela...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 499.5KB)
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- Publisher copy:
- 10.1111/imr.12690
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Authors
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Siller-Farfán, J
Grant:
440334
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Siller-Farfán, J
Grant:
440334
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Immunological Reviews Journal website
- Volume:
- 285
- Issue:
- 1
- Publication date:
- 2018-08-11
- Acceptance date:
- 2018-06-27
- DOI:
- EISSN:
-
1600-065X
- Source identifiers:
-
860147
Item Description
- Keywords:
- Pubs id:
-
pubs:860147
- UUID:
-
uuid:9775efc3-8cf8-406b-bc9a-b0ecf18e189c
- Local pid:
- pubs:860147
- Deposit date:
- 2018-07-02
Terms of use
- Copyright holder:
- John Wiley and Sons
- Copyright date:
- 2018
- Notes:
- © 2018 John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1111/imr.12690
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