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Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection

Abstract:

The Zika virus (ZIKV) epidemic has resulted in congenital abnormalities in fetuses and neonates. Although some cross-reactive dengue virus (DENV)-specific antibodies can enhance ZIKV infection in mice, those recognizing the DENV E-dimer epitope (EDE) can neutralize ZIKV infection in cell culture. We evaluated the therapeutic activity of human monoclonal antibodies to DENV EDE for their ability to control ZIKV infection in the brains, testes, placentas, and fetuses of mice. A single dose of th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ni.3849

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Institution:
University of Oxford
Department:
H5 Human Genetics Wt Centre, NDM
Role:
Author
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Wellcome Trust More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Immunology Journal website
Volume:
18
Issue:
11
Pages:
1261-1269
Publication date:
2017-09-25
Acceptance date:
2017-09-01
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pmid:
28945244
Source identifiers:
733921
Language:
English
Pubs id:
pubs:733921
UUID:
uuid:97aa50d4-c37a-4b83-920f-fd514798845c
Local pid:
pubs:733921
Deposit date:
2018-07-24

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