Journal article
Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection
- Abstract:
-
The Zika virus (ZIKV) epidemic has resulted in congenital abnormalities in fetuses and neonates. Although some cross-reactive dengue virus (DENV)-specific antibodies can enhance ZIKV infection in mice, those recognizing the DENV E-dimer epitope (EDE) can neutralize ZIKV infection in cell culture. We evaluated the therapeutic activity of human monoclonal antibodies to DENV EDE for their ability to control ZIKV infection in the brains, testes, placentas, and fetuses of mice. A single dose of th...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Accepted manuscript, pdf, 1.3MB)
-
- Publisher copy:
- 10.1038/ni.3849
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Wellcome Trust
More from this funder
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Immunology Journal website
- Volume:
- 18
- Issue:
- 11
- Pages:
- 1261-1269
- Publication date:
- 2017-09-25
- Acceptance date:
- 2017-09-01
- DOI:
- EISSN:
-
1529-2916
- ISSN:
-
1529-2908
- Pmid:
-
28945244
- Source identifiers:
-
733921
Item Description
- Language:
- English
- Pubs id:
-
pubs:733921
- UUID:
-
uuid:97aa50d4-c37a-4b83-920f-fd514798845c
- Local pid:
- pubs:733921
- Deposit date:
- 2018-07-24
Terms of use
- Copyright holder:
- Fernandez et al
- Copyright date:
- 2017
If you are the owner of this record, you can report an update to it here: Report update to this record