Journal article icon

Journal article

An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates

Abstract:

Background. Hedgehog signalling, interpreted in receiving cells by Gli transcription factors, plays a central role in the development of vertebrate and Drosphila embryos. Many aspects of the signalling pathway are conserved between these lineages, however vertebrates have diverged in at least one key aspect: they have evolved multiple Gli genes encoding functionally-distinct proteins, increasing the complexity of the hedgehog-dependent transcriptional response. Amphioxus is one of the closest...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0000864

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Research group:
Evolution and Development Research Group
Oxford college:
Balliol College
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Research Council Functional Genetics Unit,Department of Human Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Research Council Functional Genetics Unit,Department of Human Anatomy and Genetics
Role:
Author
More by this author
Institution:
National Institute for Medical Research, London, UK
Department:
Developmental Neurobiology
Role:
Author
Biotechnology and Biological Sciences Research Council More from this funder
Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
2
Issue:
9
Article number:
e864
Publication date:
2007-09-01
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
Subjects:
UUID:
uuid:97da7dfb-0723-4d3d-961b-122b1703fe55
Local pid:
ora:1861
Deposit date:
2008-04-22

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP