Journal article
An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates
- Abstract:
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Background. Hedgehog signalling, interpreted in receiving cells by Gli transcription factors, plays a central role in the development of vertebrate and Drosphila embryos. Many aspects of the signalling pathway are conserved between these lineages, however vertebrates have diverged in at least one key aspect: they have evolved multiple Gli genes encoding functionally-distinct proteins, increasing the complexity of the hedgehog-dependent transcriptional response. Amphioxus is one of the closest...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 602.8KB)
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- Publisher copy:
- 10.1371/journal.pone.0000864
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Authors
Funding
Biotechnology and Biological Sciences Research Council
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Medical Research Council
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS One Journal website
- Volume:
- 2
- Issue:
- 9
- Article number:
- e864
- Publication date:
- 2007-09-01
- DOI:
- EISSN:
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1932-6203
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:97da7dfb-0723-4d3d-961b-122b1703fe55
- Local pid:
- ora:1861
- Deposit date:
- 2008-04-22
Related Items
Terms of use
- Copyright holder:
- S M Shimeld et al
- Copyright date:
- 2007
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Citation: Shimeld, S. M. et al. (2007). 'An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates', PLoS One 2(9), e864. [Available at http://www.plosone.org].
- Licence:
- CC Attribution (CC BY)
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