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Therapeutic effects of recombinant forms of full-length and truncated human surfactant protein D in a murine model of invasive pulmonary aspergillosis.

Abstract:

Aspergillus fumigatus (Afu) is an opportunistic fungal pathogen that can cause fatal invasive pulmonary aspergillosis (IPA) in immunocompromised individuals. Previously, surfactant protein D (SP-D), a surfactant-associated innate immune molecule, has been shown to enhance phagocytosis and killing of Afu conidia by phagocytic cells in vitro. An intranasal treatment of SP-D significantly increased survival in a murine model of IPA. Here we have examined mechanisms via which recombinant forms of...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Molecular immunology
Volume:
46
Issue:
11-12
Pages:
2363-2369
Publication date:
2009-07-01
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
Source identifiers:
243457
Language:
English
Keywords:
Pubs id:
pubs:243457
UUID:
uuid:97ecde19-53b7-4e62-8035-7158a7fa7e62
Local pid:
pubs:243457
Deposit date:
2012-12-19

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