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Trimeric HIV-1-env structures define glycan shields from clades A, B, and G

Abstract:

The HIV-1-envelope (Env) trimer is covered by a glycan shield of ∼90 N-linked oligosaccharides, which comprises roughly half its mass and is a key component of HIV evasion from humoral immunity. To understand how antibodies can overcome the barriers imposed by the glycan shield, we crystallized fully glycosylated Env trimers from clades A, B, and G, visualizing the shield at 3.4-3.7 Å resolution. These structures reveal the HIV-1-glycan shield to comprise a network of interlocking oligosaccha...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2016.04.010

Authors


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Intramural Research Program of the Vaccine Research Center More from this funder
National Institute of Allergy and Infectious Diseases More from this funder
National Institute of Diabetes and Digestive and Kidney Diseases More from this funder
National Institutes of Health More from this funder
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Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
165
Issue:
4
Pages:
813-826
Publication date:
2016-05-01
Acceptance date:
2016-04-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
618072
Language:
English
Pubs id:
pubs:618072
UUID:
uuid:97f0fc80-1187-42a8-b29b-e2e5abd65978
Local pid:
pubs:618072
Deposit date:
2016-06-06

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