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Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

Abstract:

Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P < 5 × 10-8) loci, in addition to confirming 21 previously reported loci, including multiple independent signals at 10 loci. Phenotypic stratification of UL ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-12536-4

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Role:
Author
ORCID:
0000-0002-8954-2900
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Publisher:
Nature Research Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Article number:
4857
Publication date:
2019-10-24
Acceptance date:
2019-09-10
DOI:
EISSN:
2041-1723
Pmid:
31649266
Source identifiers:
1066650
Language:
English
Keywords:
Pubs id:
pubs:1066650
UUID:
uuid:9850577d-4c53-46a7-84f4-c3772be1f15a
Local pid:
pubs:1066650
Deposit date:
2019-12-10

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