Pyocin S5 import into Pseudomonas aeruginosa reveals a generic mode of bacteriocin transport
Pyocin S5 (PyoS5) is a potent protein bacteriocin that eradicates the human pathogen Pseudomonas aeruginosa in animal infection models, but its import mechanism is poorly understood. Here, using crystallography, biophysical and biochemical analyses, and live-cell imaging, we define the entry process of PyoS5 and reveal links to the transport mechanisms of other bacteriocins. In addition to its C-terminal pore-forming domain, elongated PyoS5 comprises two novel tandemly repeated kinked 3-helix...Expand abstract
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- Peer reviewed
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- Behrens et al.
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- © 2020 Behrens et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- CC Attribution (CC BY)
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