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Pyocin S5 import into Pseudomonas aeruginosa reveals a generic mode of bacteriocin transport

Abstract:

Pyocin S5 (PyoS5) is a potent protein bacteriocin that eradicates the human pathogen Pseudomonas aeruginosa in animal infection models, but its import mechanism is poorly understood. Here, using crystallography, biophysical and biochemical analyses, and live-cell imaging, we define the entry process of PyoS5 and reveal links to the transport mechanisms of other bacteriocins. In addition to its C-terminal pore-forming domain, elongated PyoS5 comprises two novel tandemly repeated kinked 3-helix...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/mBio.03230-19

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
American Society for Microbiology Publisher's website
Journal:
mBio Journal website
Volume:
11
Issue:
2
Article number:
e03230-19
Publication date:
2020-03-10
Acceptance date:
2020-01-28
DOI:
EISSN:
2150-7511
Language:
English
Keywords:
Pubs id:
1087602
Local pid:
pubs:1087602
Deposit date:
2020-02-14

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