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Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Abstract:

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5–6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4–14%] for women born in 1940 to 22% [CI = 19–25%] for those born in 1965. Signals are driven by the gene...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41562-021-01135-3

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Institution:
University of Oxford
Division:
SSD
Department:
Sociology
Oxford college:
Nuffield College
Role:
Author
ORCID:
0000-0003-1704-0001
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Role:
Author
ORCID:
0000-0003-2445-515X
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Role:
Author
ORCID:
0000-0001-5361-2498
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Role:
Author
ORCID:
0000-0001-9048-3795
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Contributor
Role:
Contributor
Role:
Contributor
Role:
Contributor
European Research Council More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Human Behaviour Journal website
Volume:
5
Issue:
12
Pages:
1717-1730
Publication date:
2021-07-01
Acceptance date:
2021-05-14
DOI:
EISSN:
2397-3374
Pmid:
34211149

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