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Thesis

Analysis of the human B cell repertoire following vaccination

Abstract:

A diverse B cell repertoire is essential for recognition and response to infectious and vaccine antigens. High-throughput sequencing of B cell receptor (BCR) genes can now be used to study the B cell repertoire at a depth which reflects its true diversity. As a relatively new technology, there is little information on the structure of the repertoire at baseline, whether antigen-specific changes can be detected from the total repertoire following antigen stimulus, and what the potential cli...

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Division:
MSD
Department:
Paediatrics
Department:
Paediatrics
Role:
Author

Contributors

Department:
Paediatrics
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Supervisor
Department:
GSK
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Examiner
Department:
Kymab
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:98f0fe4a-993a-4e31-af0c-24ac7e638d29
Deposit date:
2016-10-18

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