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Thesis

Mechanistic studies on 2-oxoglutarate dependent oxygenases

Abstract:

The first identfied 2-oxoglutarate (2OG) dependent oxygenase was a collagen modifying enzyme in the work by Hutton et al. in 1967. Subsequent work has revealed that 2OG dependent oxygenases are a large family with diverse biological roles. With small molecule substrates, these enzymes catalyse a wide range of oxidative reactions, including those that form part of antibiotic biosynthetic pathways. The currently accepted consensus mechanism for catalysis by 2OG-dependent oxygenases ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Research group:
Prof. Christopher J. Schofield
Oxford college:
St Peter's College
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Supervisor
More from this funder
Funding agency for:
Szollossi, A
Grant:
"Open Horizons"
Publication date:
2012
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK

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