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Thesis

Investigations into the regulation of sister chromatid cohesion

Abstract:

Cohesin, a ring-shaped complex composed of four subunits, is an essential player involved in timely and accurate segregation of genetic material at mitosis and meiosis. Cohesin performs a highly conserved role by topologically embracing sister chromatids until their concerted disjunction at anaphase, when the α-kleisin subunit of the ring is irreversibly cleaved by separase. A central part of the cohesin cycle is its cleavage-independent removal from chromatin through the action of the rel...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Prof Kim Nasmyth's lab
Oxford college:
Trinity College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
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Funding agency for:
Kozyrska, K
Publication date:
2014
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:9964dcc5-9280-4abd-a30b-a6ccba8632a0
Local pid:
ora:9427
Deposit date:
2014-11-27

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