Journal article
Plasma membrane Ca2+ ATPase 1 is required for maintaining atrial Ca2+ homeostasis and electrophysiological stability in the mouse
- Abstract:
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To determine the role of PMCA1 in maintaining Ca2+ homeostasis and electrical stability in the atrium under physiological and stress conditions, mice with a cardiomyocyte-specific deletion of PMCA1 (PMCA1cko) and their control littermates (PMCA1loxP/loxP) were studied at the organ and cellular levels. At the organ level, the PMCA1cko hearts became more susceptible to atrial arrhythmias under rapid programmed electrical stimulation (PES) compared with the PMCA1loxP/loxP hearts, and such arrh...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1113/JP274110
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Authors
Funding
+ British Heart Foundation
More from this funder
Grant:
PG/14/80/31106,
PG/16/67/32340, PG/12/21/29473, PG/11/59/29004 ML, EC
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Journal of Physiology Journal website
- Volume:
- 595
- Issue:
- 24
- Pages:
- 7383–7398
- Publication date:
- 2017-11-09
- Acceptance date:
- 2017-10-06
- DOI:
- ISSN:
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1469-7793
Item Description
- Keywords:
- Pubs id:
-
pubs:734126
- UUID:
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uuid:9983948b-b940-4458-b66b-ba3536cf03f2
- Local pid:
- pubs:734126
- Deposit date:
- 2017-10-06
Terms of use
- Copyright holder:
- Wang et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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