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Plasma membrane Ca2+ ATPase 1 is required for maintaining atrial Ca2+ homeostasis and electrophysiological stability in the mouse

Abstract:

To determine the role of PMCA1 in maintaining Ca2+ homeostasis and electrical stability in the atrium under physiological and stress conditions, mice with a cardiomyocyte-specific deletion of PMCA1 (PMCA1cko) and their control littermates (PMCA1loxP/loxP) were studied at the organ and cellular levels. At the organ level, the PMCA1cko hearts became more susceptible to atrial arrhythmias under rapid programmed electrical stimulation (PES) compared with the PMCA1loxP/loxP hearts, and such arrh...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1113/JP274110

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More from this funder
Grant:
G10002647, G1002082, ML, EC
More from this funder
Grant:
PG/14/80/31106, PG/16/67/32340, PG/12/21/29473, PG/11/59/29004 ML, EC
Publisher:
Wiley Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
595
Issue:
24
Pages:
7383–7398
Publication date:
2017-11-09
Acceptance date:
2017-10-06
DOI:
ISSN:
1469-7793
Keywords:
Pubs id:
pubs:734126
UUID:
uuid:9983948b-b940-4458-b66b-ba3536cf03f2
Local pid:
pubs:734126
Deposit date:
2017-10-06

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