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ALK2 receptor kinase association with FKBP12.6 is structurally conserved with the ALK2-FKBP12 complex

Abstract:

The immunophilin FKBP12 is a known inhibitor of type I BMP and TGF-β receptors that competes for binding with their substrate SMADs. FKBP12 and the close paralog FKBP12.6 additionally assemble with ryanodine receptors to control Ca2+ release. Binding of FKBP12.6 to BMP/TGF-β receptors has yet to be investigated, but appears plausible given its high sequence similarity to FKBP12. Here, we found that FKBP12.6 can assemble with BMP and TGF-β-family type I receptors, but not with type II receptor...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/biomedicines9020129

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Role:
Author
ORCID:
0000-0002-1331-9518
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
ORCID:
0000-0001-6757-0436
Publisher:
MDPI Publisher's website
Journal:
Biomedicines Journal website
Volume:
9
Issue:
2
Article number:
129
Publication date:
2021-01-29
Acceptance date:
2021-01-26
DOI:
EISSN:
2227-9059
Language:
English
Keywords:
Pubs id:
1159192
Local pid:
pubs:1159192
Deposit date:
2021-02-01

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