Journal article
ALK2 receptor kinase association with FKBP12.6 is structurally conserved with the ALK2-FKBP12 complex
- Abstract:
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The immunophilin FKBP12 is a known inhibitor of type I BMP and TGF-β receptors that competes for binding with their substrate SMADs. FKBP12 and the close paralog FKBP12.6 additionally assemble with ryanodine receptors to control Ca2+ release. Binding of FKBP12.6 to BMP/TGF-β receptors has yet to be investigated, but appears plausible given its high sequence similarity to FKBP12. Here, we found that FKBP12.6 can assemble with BMP and TGF-β-family type I receptors, but not with type II receptor...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 2.6MB)
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- Publisher copy:
- 10.3390/biomedicines9020129
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Bibliographic Details
- Publisher:
- MDPI Publisher's website
- Journal:
- Biomedicines Journal website
- Volume:
- 9
- Issue:
- 2
- Article number:
- 129
- Publication date:
- 2021-01-29
- Acceptance date:
- 2021-01-26
- DOI:
- EISSN:
-
2227-9059
Item Description
Terms of use
- Copyright holder:
- E Williams et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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