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Thesis

Modulators of MHC class I-related protein 1-mediated antigen presentation

Abstract:

The monomorphic MHC class I-related protein 1 (MR1) presents bacterial metabolites to mucosal-associated invariant T (MAIT) cells, an innate-like subset of T lymphocytes. The known MAIT-activating MR1 ligands are intermediates of riboflavin synthesis, a pathway specific to certain fungi and bacteria and, thus, intrinsically non-self for humans. Here, a combination of hypothesis-generating and hypothesis-testing approaches was used to identify novel modulators of this non-classical antigen ...

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Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author

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Supervisor
Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Kulicke, CA
Grant:
105401/Z/14/Z
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
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UUID:
uuid:99c881ef-5829-4a81-b99e-8c6f4d65d323
Deposit date:
2019-04-07

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