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Lamin B1 controls oxidative stress responses via Oct-1

Abstract:

Interactions of lamins with chromatin and transcription factors regulate transcription. Oct-1 has previously been shown to colocalize partly with B-type lamins and is essential for transcriptional regulation of oxidative stress response genes. Using sequential extraction, co-immunoprecipitation (IP), fluorescence loss in photobleaching, and fluorescence resonance energy transfer, we confirm Oct-1-lamin B1 association at the nuclear periphery and show that this association is lost in Lmnb1

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1083/jcb.200804155

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Lincoln College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Tim and Kit Kemp More from this funder
Edward Penley Abraham Trust More from this funder
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
184
Issue:
1
Pages:
45-55
Publication date:
2009-01-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Language:
English
Subjects:
UUID:
uuid:99ffbcee-71cb-45fc-acff-2e664eda935d
Local pid:
ora:3403
Deposit date:
2010-02-24

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