Journal article
HIV-1 promotes the degradation of components of the Type 1 IFN JAK/STAT 1 pathway and blocks antiviral ISG induction
- Abstract:
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Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-a only has a modest impact on HIV-1 infection, suggesting its possible targeting by HIV. Here, we report that the HIV protein, Vif, inhibits effective IFN-a signalling via degradation of essential JAK/STAT pathway components. We found that STAT1 and STAT3 are specifically reduced in HEK293T cells expressi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.3MB)
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- Publisher copy:
- 10.1016/j.ebiom.2018.03.006
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Authors
Funding
+ Science Foundation Ireland
More from this funder
Funding agency for:
Stevenson, N
Grant:
16/TIDA/4139
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- EBioMedicine Journal website
- Volume:
- 30
- Pages:
- 203-216
- Publication date:
- 2018-03-08
- Acceptance date:
- 2018-03-07
- DOI:
- ISSN:
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2352-3964
- Source identifiers:
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828263
Item Description
- Keywords:
- Pubs id:
-
pubs:828263
- UUID:
-
uuid:9a04a209-189a-43f7-9a48-67f287bf451c
- Local pid:
- pubs:828263
- Deposit date:
- 2018-03-07
Terms of use
- Copyright holder:
- © 2018 Published by Elsevier BV
- Copyright date:
- 2018
- Notes:
- This is an Open Access article published under a Creative Commons Licence, see: https://creativecommons.org/licenses/by-nc-nd/4.0/
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