Journal article
Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus
- Abstract:
-
We have produced Csf1r-deficient rats by homologous recombination in embryonic stem cells. Consistent with the role of Csf1r in macrophage differentiation, there was a loss of peripheral blood monocytes, microglia in the brain, epidermal Langerhans cells, splenic marginal zone macrophages, bone-associated macrophages and osteoclasts, and peritoneal macrophages. Macrophages of splenic red pulp, liver, lung, and gut were less affected. The pleiotropic impacts of the loss of macrophages on devel...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- American Association of Immunologists Publisher's website
- Journal:
- Journal of Immunology Journal website
- Volume:
- 201
- Issue:
- 9
- Pages:
- 2683-2699
- Publication date:
- 2018-11-01
- Acceptance date:
- 2018-08-20
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Pmid:
-
30249809
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:923863
- UUID:
-
uuid:9a0db852-f79e-475d-81dc-6ba2cd7ac4ce
- Local pid:
- pubs:923863
- Source identifiers:
-
923863
- Deposit date:
- 2018-11-14
Terms of use
- Copyright holder:
- Pridans et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 The Authors. This article is distributed under the terms of the CC BY 4.0 Unported license.
- Licence:
- CC Attribution (CC BY)
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